Curriculum vitae

Prof.universitario Dr. Med. Carsten Tschöpe
Vice-director y medico jefe dirigente

Clinica medicinal II
Cardiología y Pulmología
Charité – medicina universitaria Berlin
Campus Virchow




                  
 

Calificaciones adicionales

  • especialista en medicina interna
  • especialista en cardiología
  • medicina de salvamento
  • diagnóstico MRT

Premios y menciones honoríficos

1998 – premio de insuficiencia cardíaca MSD
1999 – premio de investigaciones BMS
2000 – premio de investigaciones UKBF
2001 – premio de investigaciones UKBF .—
2004 – premio para poster sobre insuficiencia cardìaca de la DKG
2006 – premio de investigaciones de la Asociación de diabetología europea
2007 – Beca de Charité para la habilitación
2008 – BCRT-Kick off Grand

Socio en gremios cientificos

  • Sociedad alemana de cardiología
  • Sociedad alemana de medicina interna
  • Liga alemana para combatir la presión alta
  • Sociedad europea de cardiología (ESC)
  • Sociedad americana de cardiología
  • Fundación europea para diabetes mellitus
  • grupo de estudios sobre defectos de corazón diastólicos ESC
  • Nukleus de la AG 10 :insuciencia cardíaca de la DKG

Jefe de de estudios clínicos

 - para tratamiento de hipertonía  Real-Study
 - para la insuficiencia de la válvula mitral  Evolución I , Evolución II – estudio
 - para insuficiencia diastólica de corazón  I-Preserve, estudio DDD, Fibro-Aldo
 - para insuficia cardíaca aguda  estudio veritas-2
 - para insuficiencia cardíaca crónica  estudio escape
 - para la terápia célula madre en DMCI  Steb 1 (proyecto)
 - para la terápia célula madre en pAVK  estudio PLX-PAD

Publicaciones científicas

250 publicaciones (incl.sumario y títulos de libros, 170 artículos internacionales auténticos)

PUB MED

seleccionadas publicaciones importantes de los últimos anos

  1. Franssen C, Chen S, Unger A, Korkmaz HI, De Keulenaer GW, Tschöpe C, Leite-Moreira AF, Musters R, Niessen HW, Linke WA, Paulus WJ, Hamdani N.  Microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction. JACC Heart Fail. 2016 4:312-24
  2. Templin C., Ghadri J.R., Diekmann J., Napp L.C., Bataiosu D.R., Jaguszewski M., Cammann V.L., Sarcon A., Geyer V., Neumann C.A., Seifert B., Hellermann J., Schwyzer M., Eisenhardt K., Jenewein J., Franke J., Katus H.A., Burgdorf C., Schunkert H., Moeller C., Thiele H., Bauersachs J., Tschöpe C., Schultheiss H.P., Laney C.A., Rajan L., Michels G., Pfister R., Ukena C., Böhm M., Erbel R., Cuneo A., Kuck K.H., Jacobshagen C., Hasenfuss G., Karakas M., Koenig W., Rottbauer W., Said S.M., Braun-Dullaeus R.C., Cuculi F., Banning A., Fischer T.A., Vasankari T., Airaksinen K.E.J., Fijalkowski M., Rynkiewicz A., Pawlak M., Opolski G., Dworakowski R., MacCarthy P., Kaiser C., Osswald S., Galiuto L., Crea F., Dichtl W., Franz W.M., Empen K., Felix S.B., Delmas C., Lairez O., Erne P., Bax J.J., Ford I., Ruschitzka F., Prasad A. ,  Lüscher T.F. Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy. New Engl J Med. 2015;373(10):929-38.
  3. Schmidt-Lucke C, Zobel T, Schrepfer S, Kühl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschöpe C. Impaired endothelial regeneration through human parvovirus B19-infected circulating angiogenic cells in cardiomyopathy. J Infect Dis2015 in press
  4. Spillmann F, Van Linthout S, Miteva K, Lorenz M, Stangl V, Schultheiss HP, Tschöpe C. induced endothelial dysfunction in the absence of its cholesterolmodulating effects. 2014 Jan;232(1):1-9
  5. Van Linthout S, Miteva K, Tschöpe C. Crosstalk between fibroblasts and inflammatory cells. Cardiovasc Res. 2014 May 1;102(2):258-69
  6. Savvatis K, Pappritz K, Becher PM, Lindner D, Zietsch C, Volk HD, Westermann D, Schultheiss HP, Tschöpe C. Interleukin-23 deficiency leads to impaired wound healing and adverse prognosis after myocardial infarction. Circ Heart Fail. 2014 Jan;7(1):161-71
  7. Paulus WJ, Tschöpe C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J Am Coll Cardiol. 2013 Jul 23;62(4):263-71.
  8. Kasner M, Westermann D, Steendijk P, Dröse S, Poller W, Schultheiss HP, Tschöpe C. Left ventricular dysfunction induced by nonsevere idiopathic pulmonary arterial hypertension: a pressure-volume relationship study. Am J Respir Crit Care Med. 2012 Jul 15;186(2):181-9.
  9. Kasner, Westermann D, Lopez B, Gaub R, Escher F, Kühl U, Schultheiss HP, Tschöpe C. Diastolic tissue Doppler indices correlate with the degree of collagen expression and cross-linking in heart
    failure and normal ejection fraction. J Am Coll Cardiol;2011,57:977-85.
  10. Westermann D, Savvatis K, Lettau O, Lindner D, Zietsch C, Escher F, Plendl J, Riad A, Schultheiss HP, Tschöpe C. Gene deletion of the matrix metalloproteinase-2 exacerbates CVB-3 induced myocarditis. Circulation, 2011, 8;124:2082-93.
    pdf - Westermann et al 2011
  11. Miteva K, Haag M, Peng J, Savvatis K, Becher PM, Seifert M, Warstat K, Westermann D, Ringe J, Sittinger M, Schultheiss HP, Tschöpe C*, Van Linthout S*. Human cardiac-derived adherent proliferating cells reduce murine acute coxsackievirus B3-induced myocarditis. *contributed equally. PLoS One. 2011;6:e28513.  pdf - Miteva et al 2011
  12. Knöll R, Kostin S, Klede S, Savvatis K, Klinge L, Stehle I, Gunkel S, Kötter S, Babicz K, Sohns M, Miocic S, Didié M, Knöll G, Zimmermann WH, Thelen P, Bickeböller H, Maier L, Schaper W, Schaper J, Kraft T, Tschöpe C, Linke WA, Chien KR. A common MLP (Muscle LIM Protein) variant is associated with cardiomyopathy. Circ Res. 2010 5;106:695-704.
  13. Tschöpe C, Paulus WJ. Is echocardiographic evaluation of diastolic function useful in determining clinical care? Doppler echocardiography yields dubious estimates of left ventricular diastolic pressures. Circulation 2009 ;120:810-20
  14. Westermann D, Walther T, Savvatis K, Sobirey M, Riad A, Bader M, Schultheiss HP, Tschöpe C. Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 2009 Mar 10. [Epub ahead of print].
  15. Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, Stangl V, De Geest B, Schultheiss HP, Tschöpe C . Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension. 2009;53:682-7.
  16. Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U, Kroemer HK, Schultheiss HP, Tschöpe C. Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009,15;69:695-9.
  17. Van Linthout S, Spillmann F, Riad A, Trimpert C, Lievens J, Meloni M, Escher E, Filenberg E; Demir O, Li J, Shakibaei M, Schimke I, Staudt A, Felix SB, Schultheiss HP, De Geest B, Tschöpe C. Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation; 2008, 117:1563-1573.
  18. Westermann D, Kasner M, Steendijk P, Spillmann F, Poller W, Pauschinger M, Schultheiss HP, Tschöpe C. An impaired Frank-Starling response during enhanced cardiac demand causing heart failure symptoms in patients with diastolic abnormalities. Circulation; 2008, 117:2051-2060.
  19. Holzmann M, Nicko A, Kühl U, Noutsias M, Poller W, Hoffmann W, Morguet A, Witzenbichler B, Tschöpe C, Schultheiss HP, Pauschinger M. Complication rate in right ventricular endomyocardial biopsy - A retro- and prospective study over a 11 year period analyzing 3048 diagnostic procedures. Circulation; 2008, 52:1068-75 .
  20. Riad A, Jäger S, Kallwellis-Opara A, Sobirey M, Escher F, Yaulema-Riß A, Karatas A, Heimesaat M, Bereswill S, Dragun D, Pauschinger M, Schultheiss HP, Tschöpe C: lmproved survival rate in Toll-Like Receptor-4 deficient mice after induction of myocardial infarction. J Immunology; 2008, 15180:6954-61.
  21. Westermann D, Mersmann J, Melchior A, Petrik C, Freudenberger T, lettau O, Schaefer L, Lüllmann-Rauch R, Jacoby C, Schader J, Branmd-Herrmann SM, Young MF, Levkau B, Baba HH, Schultheiss HP, Unger Th, Zacharowski K, Tschöpe C, Fischer J. Biglycan is required for adaptive remodelling after myocardial infraction. Circulation; 2008, 11; 117:1269-76.
  22. Kasner M, Westermann D, Steendijk P, Gaub R, Wilkenshoff U, Weitmann K, Hoffmann W, Poller W, Schultheiss HP, Pauschinger M, Tschöpe C. Utility of Doppler echocardiography and tissue Doppler imaging in the estimation of diastolic function in heart failure with normal ejection fraction: a comparative Doppler-conductance catheterization study. Circulation; 2007, 7; 116:637-47.
  23. Paulus WJ, Tschöpe C, Sanderson JE, Rusconi C, Flachskampf FA, Rademakers FE, Marino P, Smiseth OA, De Keulenaer G, Leite-Moreira AF, Borbely A, Edes I, Handoko ML, Heymans S, Pezzali N, Pieske B, Dickstein K, Fraser AG, Brutsaert DL. How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology. Eur Heart J.; 2007, 28:2539-50.
  24. Westermann D, Rutschow S, Jager S, Linderer A, Anker S, Riad A, Unger T, Schultheiss HP, Pauschinger M, Tschöpe C. Contributions of inflammation and cardiac matrix metalloproteinase activity to cardiac failure in diabetic cardiomyopathy: the role of Angiotensin type 1 receptor antagonism. Diabetes.; 2007, 56:641-6.
  25. Tschöpe C, Bock CT, Kasner M, Noutsias M, Westermann D, Schwimmbeck PL, Pauschinger M, Poller WC, Kühl U, Kandolf R, Schultheiss H-P. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation; 2005, 111:879-86.
  26. Witzenbichler B, Westermann D, Knueppel S, Schultheiss HP, Tschöpe C. Protective role of angiopoietin-1 in endotoxic Shock. Circulation; 2005, 111:97-105.
  27. Tschöpe C, Walther T, Escher E, Spillmann F, Jing Du, Altmann C, Schimke I, Bader M, Sanchez-Ferrer CF, Schultheiss HP, Noutsias M. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiopathy. FASEB J; 2005, 19: 2057-9.
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